Jose de Leon Selected Research

Clozapine (Clozaril)

5/2022	Optimization of therapy in patients with epilepsy and psychiatric comorbidities: key points.
3/2022	An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.
1/2022	Precision psychiatry: The complexity of personalizing antipsychotic dosing.
1/2022	Clozapine and the risk of haematological malignancies.
1/2022	Screening the European pharmacovigilance database for reports of clozapine-related DRESS syndrome: 47 novel cases.
1/2022	Best Practices for Starting Clozapine in Patients With Schizophrenia: How to Switch From the Prior Antipsychotic(s).
1/2022	Association between myocarditis and antipsychotics other than clozapine: a systematic literature review and a pharmacovigilance study using VigiBase.
7/2021	Clozapine-associated myocarditis in the World Health Organization's pharmacovigilance database: Focus on reports from various countries.
6/2021	The association of clozapine and haematological malignancies needs to be replicated by other studies and more importantly by analyses of subsamples from VigiBase.
3/2021	European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed.

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Jose de Leon Research Topics

Disease

25	Schizophrenia (Dementia Praecox) 01/2022 - 10/2002
21	Drug-Related Side Effects and Adverse Reactions 03/2022 - 08/2003
15	Obesity 03/2022 - 02/2005
12	Inflammation (Inflammations) 03/2022 - 09/2017
11	Infections 05/2021 - 09/2003
9	Mental Disorders (Mental Disorder) 05/2022 - 06/2005
9	Weight Gain 10/2018 - 09/2006
8	Bipolar Disorder (Manic Depressive Psychosis) 05/2022 - 05/2007
8	Myocarditis (Carditis) 03/2022 - 01/2016
8	Pneumonia (Pneumonitis) 03/2022 - 11/2017
6	Psychotic Disorders (Schizoaffective Disorder) 05/2022 - 08/2004
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2012 - 05/2007
6	Hyperlipidemias (Hyperlipidemia) 09/2011 - 05/2007
6	Tobacco Use Disorder (Nicotine Dependence) 09/2006 - 09/2002
5	Treatment-Resistant Schizophrenia 01/2022 - 02/2007
5	Fever (Fevers) 01/2020 - 09/2003
4	Catatonia 05/2019 - 01/2017
4	Body Weight (Weight, Body) 10/2018 - 03/2012
4	Hypertension (High Blood Pressure) 03/2012 - 09/2006
4	Tardive Dyskinesia 12/2009 - 10/2005
3	Agranulocytosis (Granulocytopenia) 03/2022 - 01/2019
3	Constipation 05/2021 - 08/2003
3	Intellectual Disability (Idiocy) 03/2019 - 07/2009
3	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2019 - 01/2013
3	Pain (Aches) 01/2018 - 01/2015
3	Hypercholesterolemia 03/2012 - 01/2008
3	Hypertriglyceridemia 12/2009 - 09/2006
3	Substance-Related Disorders (Drug Abuse) 04/2008 - 07/2002
2	Neoplasms (Cancer) 01/2022 - 06/2021
2	COVID-19 01/2020 - 01/2020
2	Hemorrhage 01/2020 - 03/2012
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/2019 - 01/2019
2	Mania (Manias) 12/2018 - 05/2015
2	Myoclonus (Nocturnal Myoclonus) 01/2018 - 09/2003
2	Alcoholism (Alcohol Abuse) 01/2018 - 11/2005
2	Nausea 03/2016 - 10/2015
2	Torsades de Pointes (Torsade de Pointes) 01/2016 - 05/2014
2	Respiratory Tract Infections (Respiratory Tract Infection) 08/2004 - 09/2003
2	Polydipsia 02/2003 - 10/2002
1	Epilepsy (Aura) 05/2022
1	Seizures (Absence Seizure) 05/2022
1	Drug Hypersensitivity Syndrome 01/2022
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 05/2019
1	Airway Obstruction (Choking) 03/2019
1	Dementia (Dementias) 03/2019
1	Deglutition Disorders (Dysphagia) 03/2019
1	Heat Stroke (Heatstroke) 01/2019

Drug/Important Bio-Agent (IBA)

45	Clozapine (Clozaril)FDA LinkGeneric 05/2022 - 02/2003
34	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 07/2002
14	Pharmaceutical PreparationsIBA 03/2022 - 10/2002
12	Olanzapine (Zyprexa)FDA Link 01/2022 - 08/2004
9	Valproic Acid (Depakote)FDA LinkGeneric 05/2022 - 06/2009
6	Quetiapine Fumarate (Seroquel)FDA Link 01/2022 - 05/2007
5	Risperidone (Risperdal Consta)FDA LinkGeneric 09/2017 - 01/2005
5	Triglycerides (Triacylglycerol)IBA 10/2015 - 05/2007
5	ORALIT (ORS)IBA 09/2015 - 02/2005
5	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2010 - 08/2003
4	Lamotrigine (Lamictal)FDA LinkGeneric 05/2022 - 05/2007
4	Oral ContraceptivesIBA 03/2022 - 01/2020
4	Antidepressive Agents (Antidepressants)IBA 01/2020 - 12/2002
4	Glucose (Dextrose)FDA LinkGeneric 10/2015 - 05/2007
3	Topiramate (Topamax)FDA LinkGeneric 05/2022 - 03/2012
3	Carbamazepine (Tegretol)FDA LinkGeneric 05/2022 - 05/2007
3	Fluvoxamine (Luvox)FDA LinkGeneric 05/2021 - 01/2020
3	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 12/2009
3	Oxcarbazepine (Trileptal)FDA LinkGeneric 05/2019 - 05/2007
3	Caffeine (No Doz)FDA LinkGeneric 05/2015 - 01/2004
3	ziprasidone (Geodon)FDA Link 01/2014 - 09/2006
3	LipidsIBA 03/2012 - 05/2007
3	HDL CholesterolIBA 03/2012 - 05/2007
2	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 05/2022 - 12/2002
2	C-Reactive ProteinIBA 03/2022 - 01/2020
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2020 - 10/2005
2	Biological ProductsIBA 01/2018 - 10/2002
2	BenzodiazepinesIBA 01/2017 - 12/2002
2	Aripiprazole (Abilify)FDA Link 12/2016 - 07/2009
2	Metformin (Glucophage)FDA LinkGeneric 03/2016 - 10/2015
2	Haloperidol (Haldol)FDA LinkGeneric 01/2016 - 09/2011
2	Insulin (Novolin)FDA Link 10/2015 - 03/2012
2	CholesterolIBA 10/2015 - 05/2007
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 05/2014 - 01/2013
2	Acetyl-CoA CarboxylaseIBA 12/2009 - 01/2008
2	Neuropeptide YIBA 12/2009 - 01/2008
2	Chlorpromazine (Thorazine)FDA Link 12/2009 - 01/2008
2	norclozapineIBA 02/2007 - 09/2003
2	SmokeIBA 09/2006 - 09/2002
1	Bupropion (Wellbutrin)FDA LinkGeneric 05/2022
1	perampanelIBA 05/2022
1	Levetiracetam (Keppra)FDA LinkGeneric 05/2022
1	Maprotiline (Ludiomil)FDA Link 05/2022
1	TabletsIBA 05/2021
1	Perphenazine (Trilafon)FDA LinkGeneric 05/2021
1	Anti-Infective Agents (Microbicides)IBA 12/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Factor V (Coagulation Factor V)IBA 03/2019
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 01/2019

Therapy/Procedure

5	Therapeutics 05/2022 - 09/2006
3	Polypharmacy 12/2019 - 01/2010
3	Duration of Therapy 12/2009 - 02/2005
2	Self Medication 09/2006 - 03/2005